During the first 24 hours of their lives, maternal antigens are absorbed through the pups' intestines which are very, very thin during those first few hours. After the colozturm ceases a day or so later, the maternal antigens decline steadily. During this time, puppies cannot build up their own natural immunity because the passive immunity gets in the way.
As the passive immunity gradually declines, the pup's immune system takes over. At this time, the pups should be given their first immunization shots so they can build up their own antibodies. This is why puppies should get several vaccinations at two to four week intervals until they are around 16 to 18 weeks old. This maximizes the chance of catching the puppy's immune system as soon as it is ready to respond, minimizing the amount of time the puppy may be susceptible to infection. The last shot should be given after four months of age to be sure that the dam's antibodies have not gotten in the way of the pup building up its own immunity.
Puppies should not be separated from their mother and litter mates before eight weeks of age. Many breeders recommend a minimum of 10 weeks. This is related to physical considerations such as weaning, and psychological considerations such as the puppy's readiness to leave the litter.
Many breeders believe it is best to not bring home two puppies together. They tend to bond to each other, and not to you, which can cause serious problems when the time comes to train them. Having two puppies needing house training at the same time can make that process go on for much longer. There are always exceptions, of course, and there are many happy dogs that were litter mates or were adopted at the same time.
About the Author:
Being a puppy lover, I have been training puppies from young. I have learnt/watched cute puppy come into this world and experienced holding their delicate body. To watch some well groomed puppies, go to dog grooming .